SOAR Member Profiles

Emily Callison

• SOAR Position: Member; Peer Mentor Scholar (2024-2025); READY to SOAR Coordinator (2024-2025)
• Major: Biochemistry and Psychology
• Faculty Mentor(s): Dr. David Edward Nelson

Current Focus: Monitoring Macrophage Anti-Fungal Activity Using Live-Cell Imaging

Project Description

Cryptococcosis is a severe fungal infection caused by Cryptococcus neoformans (C. neoformans), a facultative intracellular pathogen that predominantly affects immunocompromised individuals. In the lungs, alveolar macrophages (AMs) are responsible for eliminating the infection by ingesting and killing C. neoformans. However, the pathogen has evolved sophisticated mechanisms to evade destruction by AMs, including escaping via non-lytic exocytosis (vomocytosis). Consequently, the pathogen disseminates from the lungs, posing a risk for life-threatening fungal meningitis. At present, our understanding of how C. neoformans evades destruction by AMs remains limited, as current in vitro models, such as the J774 macrophage-like cell line, do not adequately represent the AM phenotype. My research centers around the utilization of live-cell imaging as a means to understand this mechanism and to propose a more suitable in vitro model for studying the C. neoformans infection.

Why does this topic interest you?

Witnessing my sister’s battle with aplastic anemia exposed me to the profound complexities of the immune system. While her condition was autoimmune, this experience sparked a deep curiosity regarding how the body defends itself against disease and how those defenses can sometimes falter. I’m fascinated by the pivotal role macrophages play in immunity and pathogen defense. Studying macrophages and their interactions with pathogens aligns with my passion for translational medicine: understanding the science at a cellular level and imagining its potential applications in treating diseases and improving patient outcomes.

What are your professional aspirations?

I aspire to become a physician who is committed to advancing the field of medicine through impactful research, education and mentorship, and advocating for healthcare equity, particularly for individuals with intellectual and developmental disabilities. After receiving my bachelor’s degree from MTSU, I plan to attend medical school to receive a Doctorate of Medicine (M.D.).

Do you have any advice for future researchers?

Every great discovery begins with a spark of curiosity, a desire to bridge the gap between the known and unknown, and the mind of a dreamer. Though, I have found that on the path to discovery, the guidance and support of those who have walked the path before me are one of the greatest keys to success. As you embark on your research journey, remember that you are not alone. Don’t be afraid to seek support! There is no limit to what you can achieve with a bit of guidance and a whole lot of determination!

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