Soar Test

Cathrine Hasan

• SOAR Position: Peer Mentor Scholar (2025-2026); Member
• Major: Biochemistry
• Faculty Mentor(s): Dr. David Nelson

Current Focus: Investigating the Relationship Between HIF-1 Pathway Activation and the Glycolytic Shift in Fetal Liver-Derived Alveolar Like Macrophages

Additional Interests: Reading, Running, Cross-stitching

Project Description

My project investigates how Cryptococcus neoformans infection affects macrophage metabolism by studying the role of HIF-1 pathway activation in fetal liver-derived alveolar-like macrophages (FLAMs). The goal is to determine whether HIF-1 is responsible for the infection-induced shift from mitochondrial respiration to glycolysis. To test this, chemical activators and inhibitors are utilized to evaluate changes in gene expression. This research could help uncover new avenues to combat cryptococcosis in immunocompromised patients.

Why does this topic interest you?

This topic interests me because it combines several avenues of research that I am passionate about- biology, disease mechanisms, and cell-line studies. My lab provides a unique opportunity to explore how a pathogen impacts a cell line designed to model the immune response in the lungs. I’m also drawn to the balance between hands-on laboratory work, data-analysis, and scientific reading. This allows me to develop both practical lab skill and critical thinking when interpreting results and engaging with existing research in the field.

What are your professional aspirations?

My professional aspirations are centered on a career in medicine, with a specific interest in the specialty of cardiothoracic surgery. Using my background in biochemistry and disease research, I hope to expand my efforts beyond patient care through research and nonprofit work aimed at expanding access to healthcare.

Do you have any advice for future researchers?

My advice to future researchers is to take full advantage of the opportunities they’re granted—whether it’s joining a lab, attending a seminar, or even doing independent reading. Each experience helps build valuable skills and provides insight to the research process. Also, never be afraid to ask questions or seek guidance. Everyone was new to research at one point and collaboration in research is essential to the success of any project.

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